Macrophage MerTK promotes a profibrogenic cross-talk with hepatic stellate cells via soluble mediators
نویسندگان
چکیده
Background and aims: Activation of Kupffer cells recruitment monocytes are key events in fibrogenesis. These release soluble mediators which induce the activation hepatic stellate (HSC), main fibrogenic cell type within liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes macrophages has been implicated pathogenesis NASH-related fibrosis. In this study, we explored if MerTK influences profibrogenic phenotype HSCs.
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ژورنال
عنوان ژورنال: Digestive and Liver Disease
سال: 2022
ISSN: ['1590-8658', '1878-3562']
DOI: https://doi.org/10.1016/j.dld.2022.01.119